While WebHelp Section 508 output is compliant for framesets and navigation, you can make sure other elements are compliant in your topics. Assistive software needs to be able to "read" elements on the screen to visually impaired users.
In RoboHelp select File > Generate > WebHelp. Check the box labelled 508 compliant output in the additional options section of the dialog.
Use these tips to help you design an accessible system:
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If you have questions or comments or want to get involved with Adobe’s accessibility efforts, contact us. We welcome your feedback.