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Adapted from "Photoshop CS2: Essential Skills" by Mark Galer and Philip Andrews
Most if not all digital images require sharpening, even if shot on a state of the art digital megaresolution SLR with pin-sharp focusing. Most cameras or scanners can sharpen as the image is captured but the highest quality sharpening is to be found in the image editing software. Sharpening in Adobe® Photoshop® CS2 will allow you to select the precise amount of sharpening and the areas of the image that require sharpening most. If sharpening for screen it is very much a case of “what you see is what you get.” For images destined for print however, the monitor preview is just that - a preview. The actual amount of sharpening required for optimum image quality is usually a little more than looks comfortable on screen—especially when using a TFT monitor (flat panel).

The best sharpening techniques prioritize certain areas; in this case, sharpening the eyes of a portrait but avoiding the skin texture.
The basic concept of sharpening is to send the Unsharp Mask filter or Smart Sharpen filter on a “seek and manipulate” mission. These filters are programmed to make the pixels on the lighter side of any edge it finds lighter still, and the pixels on the darker side of the edge darker. Think of it as a localized contrast control. Too much and people in your images start to look radioactive (they glow), not enough and the viewers of your images start reaching for the reading glasses they don't own. The best sharpening techniques are those that prioritize the important areas for sharpening and leave the smoother areas of the image well alone, e.g. sharpening the eyes of a portrait but avoiding the skin texture. These advanced techniques are essential when sharpening images that have been scanned from film or have excessive noise, neither of which needs accentuating by the Unsharp Mask. So let the project begin.
Note: If you have any sharpening options in your capture device it is important to switch them off or set them to minimum or low (if using camera RAW set the sharpening amount to 0). The sharpening features found in most capture devices are often very crude when compared to the following technique. It is also not advisable to sharpen images that have been saved as JPEG files using high compression/low quality settings. The sharpening process that follows should also come at the end of the editing process, i.e. adjust the color and tonality of the image before starting this advanced sharpening technique. Reduce the levels of sharpening later if it proves too much.
Duplicate the background layer and set the blend mode to Overlay. Select 'Overlay' from the blend modes menu in the layers palette.
Choose Filter > Other > High Pass. Increase the pixel radius until you achieve the correct amount of sharpening. A pixel radius of 1.0 if printing to Gloss paper and 3.0 if printing to Matte paper would be about normal.

Choose Overlay from the blend modes menu in the Layers palette and then choose Filter > Other > High Pass.

Increase the pixel radius in the High Pass dialog box until you achieve the correct amount of sharpening.
Note: To adjust the level of sharpening later you can either adjust the opacity of the High Pass layer or set the blend mode of the 'High Pass' layer to 'Soft Light' or 'Hard Light' to increase or decrease the level of sharpening.
Click on the Foreground color swatch in the Tools palette to open the Color Picker. Enter 0 in the Hue and Saturation fields and 50% in the Brightness field to choose a midtone grey. Select OK. Paint the High Pass layer to remove any sharpening that is not required, e.g. skin tones, skies etc. This technique is especially useful for limiting the visual appearance of noise or film grain.

Click the Foreground color swatch in the Tools palette to open the Color Picker.

Type 0 in the Hue and Saturation fields and 50% in the Brightness field of the Color Picker.